Opportunity Information: Apply for RFA DP 22 002
The grant opportunity "Epidemiology of Lupus: Longitudinal Studies in Population-Based Cohorts" (RFA DP 22 002) is a Centers for Disease Control and Prevention (CDC), Department of Health and Human Services cooperative agreement designed to deepen what is known about lupus over the long term by leveraging cohorts that already exist. The central idea is practical: lupus is relatively rare, so building entirely new large cohorts can be slow and expensive. Instead, this funding prioritizes applicants who already have access to well-characterized lupus patient populations and can extend follow-up to capture outcomes 12 to 17 years from baseline, producing a clearer picture of how lupus unfolds across time in real-world settings.
The opportunity has two related research tracks. The first focuses on adults with lupus and supports projects that can add long-term follow-up to established adult cohorts. The second component focuses on pediatric lupus, aiming to advance knowledge using an existing cohort of children or adolescents with lupus. For pediatric studies, an important emphasis is understanding how lupus affects patients as they grow up, including key clinical and health system transitions such as moving from pediatric to adult care, and specific complications that often require coordinated long-term management (for example, nephritis and its consequences as patients enter adulthood).
Across both adult and pediatric cohorts, the research objectives are centered on treatment, access to care, long-term outcomes, disparities, and comorbidities. A major focus is examining treatment patterns and appropriateness, including medication use in general and opioid-related prescribing and appropriateness in particular. This can include documenting what people with lupus are prescribed, how treatment changes over time, and how medication choices relate to pain, function, flares, complications, and safety outcomes. Another priority area is health care access: identifying where patients experience gaps in care, barriers to specialty services, discontinuities during life transitions, or unmet needs related to both general health problems and lupus-specific complications.
The grant is also geared toward clarifying the longer-term natural history of lupus, with attention to outcomes that matter clinically and socially over many years. This includes tracking disease severity and progression, chronic pain, morbidity and mortality, disability, and quality of life, as well as the practical impacts lupus can have on daily life such as interference with work, school, and routine activities. The announcement also explicitly notes interest in assessing potential genetic factors as part of understanding long-term trajectories, which can mean incorporating existing genetic data or linking cohort data to relevant biospecimen or genotyping resources when available and appropriate.
Equity and disparities are another central theme. The CDC is looking for analyses that examine how lupus outcomes differ across groups and why, including differences by age, sex, and race/ethnicity. This can cover questions like whether certain populations experience delayed diagnosis, different access to specialists, differences in treatment intensity, higher complication rates, or worse long-term functional outcomes, and how those patterns relate to social, geographic, economic, or health system factors captured within cohorts. In addition, the opportunity calls for examining lupus comorbidities, recognizing that lupus often co-occurs with other conditions that can complicate treatment, increase risk, and shape quality of life over time.
From an administrative standpoint, this is a discretionary funding opportunity using a cooperative agreement mechanism, which typically implies substantial programmatic involvement by the funder compared with a standard grant. The award ceiling is listed as $900,000, with an expectation of around 6 awards. Eligibility is broad and includes many organization types such as state, county, and local governments; public and private institutions of higher education; tribal governments and tribal organizations; nonprofits with or without 501(c)(3) status; public housing authorities; for-profit organizations (other than small businesses); and small businesses, among others, subject to any additional eligibility clarifications in the full notice. The opportunity was created November 4, 2021, with an original application closing date of January 19, 2022, and applications were required to be submitted electronically by 5:00 pm Eastern Time on the due date.
Overall, the opportunity is aimed at producing high-value, long-horizon evidence about lupus by building on existing cohort infrastructure, with strong emphasis on real-world treatment and medication use, health care access and unmet needs, long-term clinical and functional outcomes, disparities across populations, and the role of comorbidities and potential genetic factors in shaping the course of disease.Apply for RFA DP 22 002
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Epidemiology of Lupus: Longitudinal Studies in Population-Based Cohorts" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.068.
- This funding opportunity was created on Nov 04, 2021.
- Applicants must submit their applications by Jan 19, 2022 Electronically submitted applications must be submitted no later than 500pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $900,000.00 in funding.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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